Cargando…

PRMT7 Inhibitor SGC8158 Enhances Doxorubicin-Induced DNA Damage and Its Cytotoxicity

Protein arginine methyltransferase 7 (PRMT7) regulates various cellular responses, including gene expression, cell migration, stress responses, and stemness. In this study, we investigated the biological role of PRMT7 in cell cycle progression and DNA damage response (DDR) by inhibiting PRMT7 activi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeong, Ahyeon, Cho, Yena, Cho, Minkyeong, Bae, Gyu-Un, Song, Dae-Geun, Kim, Su-Nam, Kim, Yong Kee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604017/ https://www.ncbi.nlm.nih.gov/pubmed/36293180 http://dx.doi.org/10.3390/ijms232012323

Ejemplares similares

Protein arginine methyltransferases: promising targets for cancer therapy
por: Hwang, Jee Won, et al.
Publicado: (2021)

PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation
por: Hwang, Jee Won, et al.
Publicado: (2020)

Prmt7 promotes myoblast differentiation via methylation of p38MAPK on arginine residue 70
por: Jeong, Hyeon-Ju, et al.
Publicado: (2019)

PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice
por: de Jong, Laura M., et al.
Publicado: (2022)

Targeting native and apo-sGC
por: Struthers, Mary, et al.
Publicado: (2013)

Comparison of Doxorubicin Plus Docetaxel Neoadjuvant Chemotherapy with Doxorubicin Plus Vinorelbine in Primary Breast Cancer
por: Gwak, Geumhee, et al.
Publicado: (2011)

Cancer Stem Cells as a Potential Target to Overcome Multidrug Resistance
por: Cho, Yena, et al.
Publicado: (2020)

Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC
por: Ryu, Jea-Woon, et al.
Publicado: (2017)

PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners
por: Kim, Dong-Il, et al.
Publicado: (2015)

Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection
por: Pyun, Jung-Hoon, et al.
Publicado: (2021)

Structural insights into sGC
por: Akker, Focco van den, et al.
Publicado: (2009)

Downregulation of PRMT1, a histone arginine methyltransferase, by sodium propionate induces cell apoptosis in colon cancer
por: Ryu, Tae Young, et al.
Publicado: (2019)

Relationship Between COVID-19 Infection and Risk Perception, Knowledge, Attitude, and Four Nonpharmaceutical Interventions During the Late Period of the COVID-19 Epidemic in China: Online Cross-Sectional Survey of 8158 Adults
por: Xu, Hong, et al.
Publicado: (2020)

PRMT1 loss sensitizes cells to PRMT5 inhibition
por: Gao, Guozhen, et al.
Publicado: (2019)

PRMT7 deficiency causes dysregulation of the HCN channels in the CA1 pyramidal cells and impairment of social behaviors
por: Lee, Seul-Yi, et al.
Publicado: (2020)

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor
por: Feoli, Alessandra, et al.
Publicado: (2023)

PRMT5 function and targeting in cancer
por: Kim, Hyungsoo, et al.
Publicado: (2020)

Molecular aspects of sGC regulation
por: Marletta, Michael A, et al.
Publicado: (2011)

sGC redox regulation and asthma
por: Stuehr, Dennis J, et al.
Publicado: (2015)

Inhibition of Tolaasin Cytotoxicity Causing Brown Blotch Disease in Cultivated Mushrooms Using Tolaasin Inhibitory Factors
por: Yun, Yeong-Bae, et al.
Publicado: (2023)

Effects of damage-regulated autophagy regulator gene on the SGC7901 human gastric cancer cell line
por: ZHU, BAO-SONG, et al.
Publicado: (2014)

Arginine 65 methylation of Neurogenin 3 by PRMT1 is required for pancreatic endocrine development of hESCs
por: Cho, Gahyang, et al.
Publicado: (2023)

Protein arginine methyltransferases PRMT1, PRMT4/CARM1 and PRMT5 have distinct functions in control of osteoblast differentiation
por: Dashti, Parisa, et al.
Publicado: (2023)

New clinical results with sGC stimulators
por: Behr, Jürgen
Publicado: (2011)

Synthesis and evaluation of bifunctional sGC regulators
por: Chrominski, Mikolaj, et al.
Publicado: (2013)

Conformational changes involved in sGC activation
por: Marletta, Michael A, et al.
Publicado: (2013)

Self-management levels of diet and metabolic risk factors according to disease duration in patients with type 2 diabetes
por: Cho, Sukyung, et al.
Publicado: (2018)

Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin
por: KIM, KWANG-YOUN, et al.
Publicado: (2015)

Structure and Function of Protein Arginine Methyltransferase PRMT7
por: Halabelian, Levon, et al.
Publicado: (2021)

Light-Enhanced Cytotoxicity of Doxorubicin by Photoactivation
por: Greco, Giulia, et al.
Publicado: (2023)

The Methyltransferases PRMT4/CARM1 and PRMT5 Control Differentially Myogenesis in Zebrafish
por: Batut, Julie, et al.
Publicado: (2011)

Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery
por: Kim, Ahyeon, et al.
Publicado: (2021)

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
por: Giuliani, Virginia, et al.
Publicado: (2021)

Lack of correlation between sGC subunit expression and sGC activity in cerebral development is due to non-heterodimerizing subunits in vivo
por: Haase, Nadine, et al.
Publicado: (2009)

A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide
por: Wittmann, Christine, et al.
Publicado: (2015)

Synergistic mutations in soluble guanylyl cyclase (sGC) reveal a key role for interfacial regions in the sGC activation mechanism
por: Childers, Kenneth C., et al.
Publicado: (2019)

Transactivation of bad by vorinostat-induced acetylated p53 enhances doxorubicin-induced cytotoxicity in cervical cancer cells
por: Lee, Sook-Jeong, et al.
Publicado: (2014)

Valproic Acid Induces Endocytosis-Mediated Doxorubicin Internalization and Shows Synergistic Cytotoxic Effects in Hepatocellular Carcinoma Cells
por: Saha, Subbroto Kumar, et al.
Publicado: (2017)

A molecular view of the regulation of sGC activity
por: Marletta, Michael A, et al.
Publicado: (2009)

Structural insights into sGC activation by different activators
por: van den Akker, Focco, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_nlmdp88stdhrot58i8qaa8jt54