Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and Replication

The SARS-CoV-2 virus can utilize host cell proteases to facilitate cell entry, whereby the Spike (S) protein is cleaved at two specific sites to enable membrane fusion. Furin, transmembrane protease serine 2 (TMPRSS2), and cathepsin L (CatL) are the major proteases implicated, and are thus targets f...

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Detalles Bibliográficos
Autores principales: Singh, Saravjeet, O’Reilly, Sophie, Gewaid, Hossam, Bowie, Andrew G., Gautier, Virginie, Worrall, D. Margaret
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604144/
https://www.ncbi.nlm.nih.gov/pubmed/36293378
http://dx.doi.org/10.3390/ijms232012522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604144/
https://www.ncbi.nlm.nih.gov/pubmed/36293378
http://dx.doi.org/10.3390/ijms232012522

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