Evolution of the vls Antigenic Variability Locus of the Lyme Disease Pathogen and Development of Recombinant Monoclonal Antibodies Targeting Conserved VlsE Epitopes

VlsE (variable major protein-like sequence, expressed) is an outer surface protein of the Lyme disease pathogen (Borreliella species) responsible for its within-host antigenic variation and a key diagnostic biomarker of Lyme disease. However, the high sequence variability of VlsE poses a challenge t...

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Detalles Bibliográficos
Autores principales: Li, Li, Di, Lia, Akther, Saymon, Zeglis, Brian M., Qiu, Weigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604149/
https://www.ncbi.nlm.nih.gov/pubmed/36150043
http://dx.doi.org/10.1128/spectrum.01743-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604149/
https://www.ncbi.nlm.nih.gov/pubmed/36150043
http://dx.doi.org/10.1128/spectrum.01743-22

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