Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis

Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially cytotoxic. Since M. tuberculosis can both synthesize and take up heme, the de nov...

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Detalles Bibliográficos
Autores principales: Donegan, Rebecca K., Fu, Yibo, Copeland, Jacqueline, Idga, Stanzin, Brown, Gabriel, Hale, Owen F., Mitra, Avishek, Yang, Hui, Dailey, Harry A., Niederweis, Michael, Jain, Paras, Reddi, Amit R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604157/
https://www.ncbi.nlm.nih.gov/pubmed/36169423
http://dx.doi.org/10.1128/spectrum.03604-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604157/
https://www.ncbi.nlm.nih.gov/pubmed/36169423
http://dx.doi.org/10.1128/spectrum.03604-22

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