Discovery of Simple Diacylhydrazine-Functionalized Cinnamic Acid Derivatives as Potential Microtubule Stabilizers

To develop novel microtubule-binding agents for cancer therapy, an array of N-cinnamoyl-N’-(substituted)acryloyl hydrazide derivatives were facilely synthesized through a two-step process. Initially, the antiproliferative activity of these title compounds was explored against A549, 98 PC-3 and HepG2...

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Detalles Bibliográficos
Autores principales: Zhou, Xiang, Fu, Yi-Hong, Zou, Ya-Yu, Meng, Jiao, Ou-Yang, Gui-Ping, Ge, Qiang-Sheng, Wang, Zhen-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604255/
https://www.ncbi.nlm.nih.gov/pubmed/36293224
http://dx.doi.org/10.3390/ijms232012365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604255/
https://www.ncbi.nlm.nih.gov/pubmed/36293224
http://dx.doi.org/10.3390/ijms232012365

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