Synthesis, Biological Activity and Molecular Docking of Chimeric Peptides Targeting Opioid and NOP Receptors

Recently, mixed opioid/NOP agonists came to the spotlight for their favorable functional profiles and promising outcomes in clinical trials as novel analgesics. This study reports on two novel chimeric peptides incorporating the fragment Tyr-c[D-Lys-Phe-Phe]Asp-NH(2) (RP-170), a cyclic peptide with...

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Detalles Bibliográficos
Autores principales: Wtorek, Karol, Ghidini, Alessia, Gentilucci, Luca, Adamska-Bartłomiejczyk, Anna, Piekielna-Ciesielska, Justyna, Ruzza, Chiara, Sturaro, Chiara, Calò, Girolamo, Pieretti, Stefano, Kluczyk, Alicja, McDonald, John, Lambert, David G., Janecka, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604311/
https://www.ncbi.nlm.nih.gov/pubmed/36293553
http://dx.doi.org/10.3390/ijms232012700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604311/
https://www.ncbi.nlm.nih.gov/pubmed/36293553
http://dx.doi.org/10.3390/ijms232012700

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