DR5-Selective TRAIL Variant DR5-B Functionalized with Tumor-Penetrating iRGD Peptide for Enhanced Antitumor Activity against Glioblastoma

TRAIL (TNF-related apoptosis-inducing ligand) and its derivatives are potentials for anticancer therapy due to the selective induction of apoptosis in tumor cells upon binding to death receptors DR4 or DR5. Previously, we generated a DR5-selective TRAIL mutant variant DR5-B overcoming receptor-depen...

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Detalles Bibliográficos
Autores principales: Yagolovich, Anne V., Isakova, Alina A., Artykov, Artem A., Vorontsova, Yekaterina V., Mazur, Diana V., Antipova, Nadezhda V., Pavlyukov, Marat S., Shakhparonov, Mikhail I., Gileva, Anastasia M., Markvicheva, Elena A., Plotnikova, Ekaterina A., Pankratov, Andrey A., Kirpichnikov, Mikhail P., Gasparian, Marine E., Dolgikh, Dmitry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604365/
https://www.ncbi.nlm.nih.gov/pubmed/36293545
http://dx.doi.org/10.3390/ijms232012687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604365/
https://www.ncbi.nlm.nih.gov/pubmed/36293545
http://dx.doi.org/10.3390/ijms232012687

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