Crystal Structure of CYP3A4 Complexed with Fluorol Identifies the Substrate Access Channel as a High-Affinity Ligand Binding Site

Cytochrome P450 3A4 (CYP3A4) is a major human drug-metabolizing enzyme, notoriously known for its extreme substrate promiscuity, allosteric behavior, and implications in drug–drug interactions. Despite extensive investigations, the mechanism of ligand binding to CYP3A4 is not fully understood. We de...

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Detalles Bibliográficos
Autor principal: Sevrioukova, Irina F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604483/
https://www.ncbi.nlm.nih.gov/pubmed/36293445
http://dx.doi.org/10.3390/ijms232012591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604483/
https://www.ncbi.nlm.nih.gov/pubmed/36293445
http://dx.doi.org/10.3390/ijms232012591

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