Global genome decompaction leads to stochastic activation of gene expression as a first step toward fate commitment in human hematopoietic cells

When human cord blood–derived CD34+ cells are induced to differentiate, they undergo rapid and dynamic morphological and molecular transformations that are critical for fate commitment. In particular, the cells pass through a transitory phase known as “multilineage-primed” state. These cells are cha...

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Detalles Bibliográficos
Autores principales: Parmentier, Romuald, Racine, Laëtitia, Moussy, Alice, Chantalat, Sophie, Sudharshan, Ravi, Papili Gao, Nan, Stockholm, Daniel, Corre, Guillaume, Fourel, Geneviève, Deleuze, Jean-François, Gunawan, Rudiyanto, Paldi, Andras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604949/
https://www.ncbi.nlm.nih.gov/pubmed/36288293
http://dx.doi.org/10.1371/journal.pbio.3001849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604949/
https://www.ncbi.nlm.nih.gov/pubmed/36288293
http://dx.doi.org/10.1371/journal.pbio.3001849

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