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An integrated multi-omics analysis of topoisomerase family in pan-cancer: Friend or foe?
BACKGROUND: Topoisomerases are nuclear enzymes that get to the bottom of topological troubles related with DNA all through a range of genetic procedures. More and more studies have shown that topoisomerase-mediated DNA cleavage plays crucial roles in tumor cell death and carcinogenesis. There is how...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604985/ https://www.ncbi.nlm.nih.gov/pubmed/36288358 http://dx.doi.org/10.1371/journal.pone.0274546 |