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Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis

Non-infectious cerebral venous thrombosis (CVT) is an uncommon type of cerebrovascular disease that usually affects young patients. It occurs frequently in female patients, probably due to the association of sex-specific risk factors for coagulopathies. Currently, the prognostic factors of CVT remai...

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Autores principales: Chen, Yu-Chieh, Chang, Chun-Wei, Wu, Hsiu-Chuan, Chen, Chiung-Mei, Chang, Chien-Hung, Chang, Kuo-Hsuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605230/
https://www.ncbi.nlm.nih.gov/pubmed/36294417
http://dx.doi.org/10.3390/jcm11206096
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author Chen, Yu-Chieh
Chang, Chun-Wei
Wu, Hsiu-Chuan
Chen, Chiung-Mei
Chang, Chien-Hung
Chang, Kuo-Hsuan
author_facet Chen, Yu-Chieh
Chang, Chun-Wei
Wu, Hsiu-Chuan
Chen, Chiung-Mei
Chang, Chien-Hung
Chang, Kuo-Hsuan
author_sort Chen, Yu-Chieh
collection PubMed
description Non-infectious cerebral venous thrombosis (CVT) is an uncommon type of cerebrovascular disease that usually affects young patients. It occurs frequently in female patients, probably due to the association of sex-specific risk factors for coagulopathies. Currently, the prognostic factors of CVT remain unclear. We retrospectively reviewed the clinical characteristics among 260 CVT patients, including 147 females and 113 males. A favorable clinical outcome was defined by the scores of the modified Rankin Scale (mRS) ≤ 2 at hospital discharge, while a poor clinical outcome was defined by an mRS score of 3 to 6. A headache (28.5%) was the most frequent presentation. The most commonly affected sinus was the transverse-sigmoid sinus (59.6%). Most of the cases (78.5%) were treated with anticoagulants. One hundred and fifty-seven patients (60.4%) were discharged with favorable clinical outcomes. Consciousness disturbance (odds ratio: 5.01, p < 0.001) was associated with a poor clinical outcome. Patients with poor clinical outcomes demonstrated higher D-dimer levels on admission (4137.76 ± 3317.07 vs. 2476.74 ± 2330.87 ng/mL FEU, p = 0.029) and longer hospitalization days (31.81 ± 26.29 vs. 13.96 ± 8.82 days, p < 0.001) compared with favorable clinical outcomes. These findings provide important information of clinical characteristics and prognosis for CVT. Aggressive monitoring and treatment should be considered in CVT patients with poor prognostic factors.
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spelling pubmed-96052302022-10-27 Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis Chen, Yu-Chieh Chang, Chun-Wei Wu, Hsiu-Chuan Chen, Chiung-Mei Chang, Chien-Hung Chang, Kuo-Hsuan J Clin Med Article Non-infectious cerebral venous thrombosis (CVT) is an uncommon type of cerebrovascular disease that usually affects young patients. It occurs frequently in female patients, probably due to the association of sex-specific risk factors for coagulopathies. Currently, the prognostic factors of CVT remain unclear. We retrospectively reviewed the clinical characteristics among 260 CVT patients, including 147 females and 113 males. A favorable clinical outcome was defined by the scores of the modified Rankin Scale (mRS) ≤ 2 at hospital discharge, while a poor clinical outcome was defined by an mRS score of 3 to 6. A headache (28.5%) was the most frequent presentation. The most commonly affected sinus was the transverse-sigmoid sinus (59.6%). Most of the cases (78.5%) were treated with anticoagulants. One hundred and fifty-seven patients (60.4%) were discharged with favorable clinical outcomes. Consciousness disturbance (odds ratio: 5.01, p < 0.001) was associated with a poor clinical outcome. Patients with poor clinical outcomes demonstrated higher D-dimer levels on admission (4137.76 ± 3317.07 vs. 2476.74 ± 2330.87 ng/mL FEU, p = 0.029) and longer hospitalization days (31.81 ± 26.29 vs. 13.96 ± 8.82 days, p < 0.001) compared with favorable clinical outcomes. These findings provide important information of clinical characteristics and prognosis for CVT. Aggressive monitoring and treatment should be considered in CVT patients with poor prognostic factors. MDPI 2022-10-16 /pmc/articles/PMC9605230/ /pubmed/36294417 http://dx.doi.org/10.3390/jcm11206096 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Yu-Chieh
Chang, Chun-Wei
Wu, Hsiu-Chuan
Chen, Chiung-Mei
Chang, Chien-Hung
Chang, Kuo-Hsuan
Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis
title Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis
title_full Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis
title_fullStr Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis
title_full_unstemmed Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis
title_short Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis
title_sort clinical characteristics and prognostic factors of non-infectious cerebral venous sinus thrombosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605230/
https://www.ncbi.nlm.nih.gov/pubmed/36294417
http://dx.doi.org/10.3390/jcm11206096
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