Cargando…
Unconventional secretion of tau by VAMP8 impacts its intra- and extracellular cleavage
In Alzheimer’s disease, Tau, a microtubule-associated protein, becomes hyperphosphorylated, detaches from microtubules, and accumulates in the somato-dendritic compartment where it forms insoluble aggregates. Tau also accumulates in the CSF of patients indicating that it is released by neurons. Cons...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605769/ https://www.ncbi.nlm.nih.gov/pubmed/36313558 http://dx.doi.org/10.3389/fcell.2022.912118 |