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Structure of trimeric pre-fusion rabies virus glycoprotein in complex with two protective antibodies

Rabies virus (RABV) causes lethal encephalitis and is responsible for approximately 60,000 deaths per year. As the sole virion-surface protein, the rabies virus glycoprotein (RABV-G) mediates host-cell entry. RABV-G’s pre-fusion trimeric conformation displays epitopes bound by protective neutralizin...

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Detalles Bibliográficos
Autores principales: Ng, Weng M., Fedosyuk, Sofiya, English, Solomon, Augusto, Gilles, Berg, Adam, Thorley, Luke, Haselon, Anna-Sophie, Segireddy, Rameswara R., Bowden, Thomas A., Douglas, Alexander D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605875/
https://www.ncbi.nlm.nih.gov/pubmed/35985336
http://dx.doi.org/10.1016/j.chom.2022.07.014