Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

Increased immune evasion by SARS-CoV-2 variants of concern highlights the need for new therapeutic neutralizing antibodies. Immunization with nanoparticles co-displaying spike receptor-binding domains (RBDs) from eight sarbecoviruses (mosaic-8 RBD-nanoparticles) efficiently elicits cross-reactive po...

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Detalles Bibliográficos
Autores principales: Fan, Chengcheng, Cohen, Alexander A., Park, Miso, Hung, Alfur Fu-Hsin, Keeffe, Jennifer R., Gnanapragasam, Priyanthi N.P., Lee, Yu E., Gao, Han, Kakutani, Leesa M., Wu, Ziyan, Kleanthous, Harry, Malecek, Kathryn E., Williams, John C., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606073/
https://www.ncbi.nlm.nih.gov/pubmed/36370711
http://dx.doi.org/10.1016/j.immuni.2022.10.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606073/
https://www.ncbi.nlm.nih.gov/pubmed/36370711
http://dx.doi.org/10.1016/j.immuni.2022.10.019

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