Gasdermin D mediates endoplasmic reticulum stress via FAM134B to regulate cardiomyocyte autophagy and apoptosis in doxorubicin-induced cardiotoxicity

Cardiomyocyte pyroptosis and apoptosis play a vital role in the pathophysiology of several cardiovascular diseases. Our recent study revealed that gasdermin D (GSDMD) can promote myocardial I/R injury via the caspase-11/GSDMD pathway. We also found that GSDMD deletion attenuated myocardial I/R and M...

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Detalles Bibliográficos
Autores principales: Qu, Ya’nan, Gao, Rifeng, Wei, Xiang, Sun, Xiaolei, Yang, Kun, Shi, Huairui, Gao, Yang, Hu, Shiyu, Wang, Yiwen, Yang, Ji’e, Sun, Aijun, Zhang, Feng, Ge, Junbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606128/
https://www.ncbi.nlm.nih.gov/pubmed/36289195
http://dx.doi.org/10.1038/s41419-022-05333-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606128/
https://www.ncbi.nlm.nih.gov/pubmed/36289195
http://dx.doi.org/10.1038/s41419-022-05333-3

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