A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer’s Disease Mice

Amyloid-β (Aβ) oligomers and protofibrils are suggested to be the most neurotoxic Aβ species in Alzheimer’s disease (AD). Hence, antibodies with strong and selective binding to these soluble Aβ aggregates are of therapeutic potential. We have recently introduced HexaRmAb158, a multivalent antibody w...

Descripción completa

Detalles Bibliográficos
Autores principales: Rofo, Fadi, Meier, Silvio R., Metzendorf, Nicole G., Morrison, Jamie I., Petrovic, Alex, Syvänen, Stina, Sehlin, Dag, Hultqvist, Greta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606191/
https://www.ncbi.nlm.nih.gov/pubmed/35939261
http://dx.doi.org/10.1007/s13311-022-01283-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606191/
https://www.ncbi.nlm.nih.gov/pubmed/35939261
http://dx.doi.org/10.1007/s13311-022-01283-y

Ejemplares similares