Cargando…

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer’s Disease Mice

Amyloid-β (Aβ) oligomers and protofibrils are suggested to be the most neurotoxic Aβ species in Alzheimer’s disease (AD). Hence, antibodies with strong and selective binding to these soluble Aβ aggregates are of therapeutic potential. We have recently introduced HexaRmAb158, a multivalent antibody w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rofo, Fadi, Meier, Silvio R., Metzendorf, Nicole G., Morrison, Jamie I., Petrovic, Alex, Syvänen, Stina, Sehlin, Dag, Hultqvist, Greta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606191/ https://www.ncbi.nlm.nih.gov/pubmed/35939261 http://dx.doi.org/10.1007/s13311-022-01283-y

Ejemplares similares

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
por: Rofo, Fadi, et al.
Publicado: (2021)

Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
por: Rofo, Fadi, et al.
Publicado: (2022)

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
por: Fang, Xiaotian T., et al.
Publicado: (2017)

Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β
por: Sehlin, Dag, et al.
Publicado: (2017)

Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain
por: Rofo, Fadi, et al.
Publicado: (2021)

Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates
por: Petersen, Inga, et al.
Publicado: (2023)

Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer’s Disease
por: Meier, Silvio R., et al.
Publicado: (2021)

Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood–brain barrier shuttle scFv8D3
por: de la Rosa, Andrés, et al.
Publicado: (2022)

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
por: Meier, Silvio R., et al.
Publicado: (2018)

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease
por: Gustavsson, Tobias, et al.
Publicado: (2020)

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer’s Disease Following Treatment with a Brain-Targeting Somatostatin Peptide
por: Rofo, Fadi, et al.
Publicado: (2021)

Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis
por: Julku, Ulrika, et al.
Publicado: (2022)

Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
por: Roshanbin, Sahar, et al.
Publicado: (2022)

Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
por: Banka, Vinay, et al.
Publicado: (2023)

ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein
por: Bonvicini, Gillian, et al.
Publicado: (2022)

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
por: Hultqvist, Greta, et al.
Publicado: (2017)

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
por: Faresjö, Rebecca, et al.
Publicado: (2021)

Standardized Preclinical In Vitro Blood–Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways
por: Morrison, Jamie I., et al.
Publicado: (2023)

Engineered antibodies: new possibilities for brain PET?
por: Sehlin, Dag, et al.
Publicado: (2019)

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer’s disease
por: Gustavsson, Tobias, et al.
Publicado: (2023)

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
por: Sehlin, Dag, et al.
Publicado: (2016)

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody
por: Syvänen, Stina, et al.
Publicado: (2018)

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
por: Faresjö, Rebecca, et al.
Publicado: (2023)

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
por: Syvänen, Stina, et al.
Publicado: (2020)

(11)C-PiB and (124)I-Antibody PET Provide Differing Estimates of Brain Amyloid-β After Therapeutic Intervention
por: Meier, Silvio R., et al.
Publicado: (2022)

Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer’s Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry
por: Kaya, Ibrahim, et al.
Publicado: (2016)

Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer’s Disease
por: Zyśk, Marlena, et al.
Publicado: (2019)

Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-Aβ-Affibodies
por: Faresjö, Rebecca, et al.
Publicado: (2022)

Mapping the binding site topology of amyloid protein aggregates using multivalent ligands
por: Sanna, Elena, et al.
Publicado: (2021)

PET Imaging in Preclinical Anti-Aβ Drug Development
por: Syvänen, Stina, et al.
Publicado: (2022)

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging
por: Schlein, Eva, et al.
Publicado: (2022)

Large Aggregates Are the Major Soluble Aβ Species in AD Brain Fractionated with Density Gradient Ultracentrifugation
por: Sehlin, Dag, et al.
Publicado: (2012)

The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers
por: van Diest, Eline, et al.
Publicado: (2023)

Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology
por: Michno, Wojciech, et al.
Publicado: (2019)

Multivalent scaffolds induce galectin-3 aggregation into nanoparticles
por: Goodman, Candace K, et al.
Publicado: (2014)

Impact of multivalent charge presentation on peptide–nanoparticle aggregation
por: Schöne, Daniel, et al.
Publicado: (2015)

Soluble Amyloid-beta Aggregates from Human Alzheimer’s Disease Brains
por: Esparza, Thomas J., et al.
Publicado: (2016)

Probing the Occurrence of Soluble Oligomers through Amyloid Aggregation Scaling Laws
por: Silva, Alexandra, et al.
Publicado: (2018)

Aggregation of Halloysite Nanotubes in the Presence of Multivalent Ions and Ionic Liquids
por: Katana, Bojana, et al.
Publicado: (2021)

Soluble aggregates of the amyloid-β peptide are trapped by serum albumin to enhance amyloid-β activation of endothelial cells
por: Reyes Barcelo, Adriana A, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_esu2kvj7u0o3p6e47b5152ftbc