Cargando…

Complement-targeted therapies in kidney transplantation—insights from preclinical studies

Aberrant activation of the complement system contributes to solid-organ graft dysfunction and failure. In kidney transplantation, the complement system is implicated in the pathogenesis of antibody- and cell-mediated rejection, ischemia-reperfusion injury, and vascular injury. This has led to the ev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anwar, Imran J., DeLaura, Isabel, Ladowski, Joseph, Gao, Qimeng, Knechtle, Stuart J., Kwun, Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606228/ https://www.ncbi.nlm.nih.gov/pubmed/36311730 http://dx.doi.org/10.3389/fimmu.2022.984090

Ejemplares similares

Harnessing the B Cell Response in Kidney Transplantation – Current State and Future Directions
por: Anwar, Imran J., et al.
Publicado: (2022)

Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery
por: Delaura, Isabel F., et al.
Publicado: (2022)

Desensitization and belatacept-based maintenance therapy in pregnancy-sensitized monkeys receiving a kidney transplant
por: Manook, Miriam, et al.
Publicado: (2023)

Gene Therapy: Will the Promise of Optimizing Lung Allografts Become Reality?
por: Gao, Qimeng, et al.
Publicado: (2022)

Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation
por: Schroder, Paul M., et al.
Publicado: (2017)

Editorial: Sensitization and Desensitization in Organ Transplantation
por: Anwar, Imran J., et al.
Publicado: (2021)

Optimal Immunosuppression Strategy in the Sensitized Kidney Transplant Recipient
por: Olaso, Danae, et al.
Publicado: (2021)

Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells
por: Song, Shengli, et al.
Publicado: (2021)

Tolerogenic therapies in transplantation
por: Page, Eugenia K., et al.
Publicado: (2012)

IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade
por: Kwun, Jean, et al.
Publicado: (2018)

Therapeutic Modulation of the Complement System in Kidney Transplantation: Clinical Indications and Emerging Drug Leads
por: Tatapudi, Vasishta S., et al.
Publicado: (2019)

Role of Complement System in Kidney Transplantation: Stepping From Animal Models to Clinical Application
por: Qi, Ruochen, et al.
Publicado: (2022)

The Role of Complement in Organ Transplantation
por: Grafals, Monica, et al.
Publicado: (2019)

Editorial: New insights into the role of complement system in liver diseases
por: Guo, Zhenya, et al.
Publicado: (2023)

Liver Transplantation for Hepatocellular Carcinoma after Downstaging or Bridging Therapy with Immune Checkpoint Inhibitors
por: Gao, Qimeng, et al.
Publicado: (2021)

Intrarenal Complement System Transcripts in Chronic Antibody-Mediated Rejection and Recurrent IgA Nephropathy in Kidney Transplantation
por: Cernoch, Marek, et al.
Publicado: (2018)

Complement Activation in Kidneys of Patients With COVID-19
por: Pfister, Frederick, et al.
Publicado: (2021)

The Complement System in Metabolic-Associated Kidney Diseases
por: Xu, Ziyu, et al.
Publicado: (2022)

Editorial: Updates on the complement system in kidney diseases
por: Bulla, Roberta, et al.
Publicado: (2023)

Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation
por: Rydenfelt, Kristina, et al.
Publicado: (2023)

Emerging New Approaches in Desensitization: Targeted Therapies for HLA Sensitization
por: Choi, Ashley Y., et al.
Publicado: (2021)

Case Report: Combined Liver-Kidney Transplantation to Correct a Mutation in Complement Factor B in an Atypical Hemolytic Uremic Syndrome Patient
por: López-Trascasa, Margarita, et al.
Publicado: (2021)

Complement in Kidney Transplantation
por: Cernoch, Marek, et al.
Publicado: (2017)

Elevated Terminal C5b-9 Complement Complex 10 Weeks Post Kidney Transplantation Was Associated With Reduced Long-Term Patient and Kidney Graft Survival
por: Witczak, Bartlomiej J., et al.
Publicado: (2021)

Contemporary Strategies and Barriers to Transplantation Tolerance
por: Ezekian, Brian, et al.
Publicado: (2018)

The role of the complement system in kidney glomerular capillary thrombosis
por: Yoshida, Yoko, et al.
Publicado: (2022)

The Complement C3a and C3a Receptor Pathway in Kidney Diseases
por: Gao, Shuang, et al.
Publicado: (2020)

Insights Into the Pathogenesis of Bullous Pemphigoid: The Role of Complement-Independent Mechanisms
por: Cole, Connor, et al.
Publicado: (2022)

Genetic investigation of Nordic patients with complement-mediated kidney diseases
por: Rydberg, Viktor, et al.
Publicado: (2023)

Weak Expression of Terminal Complement in Active Antibody-Mediated Rejection of the Kidney
por: Tiller, Gesa, et al.
Publicado: (2022)

Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys
por: Jager, Neeltina M., et al.
Publicado: (2022)

The Complement System in Kidney Transplantation
por: Santarsiero, Donata, et al.
Publicado: (2023)

Reduced Expression of Membrane Complement Regulatory Protein CD59 on Leukocytes following Lung Transplantation
por: Michielsen, Laura A., et al.
Publicado: (2018)

Treatment of Rare Inflammatory Kidney Diseases: Drugs Targeting the Terminal Complement Pathway
por: Anliker-Ort, Marion, et al.
Publicado: (2020)

Complementing the Sugar Code: Role of GAGs and Sialic Acid in Complement Regulation
por: Langford-Smith, Alex, et al.
Publicado: (2015)

Complement Factor I Variants in Complement-Mediated Renal Diseases
por: Zhang, Yuzhou, et al.
Publicado: (2022)

Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model
por: Manook, Miriam, et al.
Publicado: (2021)

Complement Nomenclature—Deconvoluted
por: Bohlson, Suzanne S., et al.
Publicado: (2019)

Pitfalls in complement analysis: A systematic literature review of assessing complement activation
por: Brandwijk, Ricardo J. M. G. E., et al.
Publicado: (2022)

Characterization of Novel P-Selectin Targeted Complement Inhibitors in Murine Models of Hindlimb Injury and Transplantation
por: Zheng, Chaowen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_d1i10i92bb300gsigal5sok9ig