Cargando…
Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor
G protein-coupled receptors (GPCRs) are important drug targets that mediate various signaling pathways by activating G proteins and engaging β-arrestin proteins. Despite its importance for the development of therapeutics with fewer side effects, the underlying mechanism that controls the balance bet...
Autores principales: | Liu, Junke, Tang, Hengmin, Xu, Chanjuan, Zhou, Shengnan, Zhu, Xunying, Li, Yuanyuan, Prézeau, Laurent, Xu, Tao, Pin, Jean-Philippe, Rondard, Philippe, Ji, Wei, Liu, Jianfeng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606269/ https://www.ncbi.nlm.nih.gov/pubmed/36289206 http://dx.doi.org/10.1038/s41467-022-34056-4 |
Ejemplares similares
-
Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics
por: Møller, Thor C., et al.
Publicado: (2018) -
Complex GABA(B) receptor complexes: how to generate multiple functionally distinct units from a single receptor
por: Xu, Chanjuan, et al.
Publicado: (2014) -
Structural basis of GABA(B) receptor–G(i) protein coupling
por: Shen, Cangsong, et al.
Publicado: (2021) -
Targeting the Brain with Single-Domain Antibodies: Greater Potential Than Stated So Far?
por: Tsitokana, Mireille Elodie, et al.
Publicado: (2023) -
Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer
por: Liu, Junke, et al.
Publicado: (2017)