Crystal structure of the Na(+)/H(+) antiporter NhaA at active pH reveals the mechanistic basis for pH sensing

The strict exchange of protons for sodium ions across cell membranes by Na(+/)H(+) exchangers is a fundamental mechanism for cell homeostasis. At active pH, Na(+)/H(+) exchange can be modelled as competition between H(+) and Na(+) to an ion-binding site, harbouring either one or two aspartic-acid re...

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Detalles Bibliográficos
Autores principales: Winkelmann, Iven, Uzdavinys, Povilas, Kenney, Ian M., Brock, Joseph, Meier, Pascal F., Wagner, Lina-Marie, Gabriel, Florian, Jung, Sukkyeong, Matsuoka, Rei, von Ballmoos, Christoph, Beckstein, Oliver, Drew, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606361/
https://www.ncbi.nlm.nih.gov/pubmed/36289233
http://dx.doi.org/10.1038/s41467-022-34120-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606361/
https://www.ncbi.nlm.nih.gov/pubmed/36289233
http://dx.doi.org/10.1038/s41467-022-34120-z

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