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Crystal structure of the Na(+)/H(+) antiporter NhaA at active pH reveals the mechanistic basis for pH sensing
The strict exchange of protons for sodium ions across cell membranes by Na(+/)H(+) exchangers is a fundamental mechanism for cell homeostasis. At active pH, Na(+)/H(+) exchange can be modelled as competition between H(+) and Na(+) to an ion-binding site, harbouring either one or two aspartic-acid re...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606361/ https://www.ncbi.nlm.nih.gov/pubmed/36289233 http://dx.doi.org/10.1038/s41467-022-34120-z |