The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which encodes a Janus kinase with critical roles in type-Ι interferon (IFN-Ι) mediated intracellular signalling. To study the role of...

Descripción completa

Detalles Bibliográficos
Autores principales: Chandra, Vikash, Ibrahim, Hazem, Halliez, Clémentine, Prasad, Rashmi B., Vecchio, Federica, Dwivedi, Om Prakash, Kvist, Jouni, Balboa, Diego, Saarimäki-Vire, Jonna, Montaser, Hossam, Barsby, Tom, Lithovius, Väinö, Artner, Isabella, Gopalakrishnan, Swetha, Groop, Leif, Mallone, Roberto, Eizirik, Decio L., Otonkoski, Timo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606380/
https://www.ncbi.nlm.nih.gov/pubmed/36289205
http://dx.doi.org/10.1038/s41467-022-34069-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606380/
https://www.ncbi.nlm.nih.gov/pubmed/36289205
http://dx.doi.org/10.1038/s41467-022-34069-z

Ejemplares similares