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The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which encodes a Janus kinase with critical roles in type-Ι interferon (IFN-Ι) mediated intracellular signalling. To study the role of...
Autores principales: | Chandra, Vikash, Ibrahim, Hazem, Halliez, Clémentine, Prasad, Rashmi B., Vecchio, Federica, Dwivedi, Om Prakash, Kvist, Jouni, Balboa, Diego, Saarimäki-Vire, Jonna, Montaser, Hossam, Barsby, Tom, Lithovius, Väinö, Artner, Isabella, Gopalakrishnan, Swetha, Groop, Leif, Mallone, Roberto, Eizirik, Decio L., Otonkoski, Timo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606380/ https://www.ncbi.nlm.nih.gov/pubmed/36289205 http://dx.doi.org/10.1038/s41467-022-34069-z |
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