Increased Aurora B expression reduces substrate phosphorylation and induces chromosomal instability

Increased Aurora B protein expression, which is common in cancers, is expected to increase Aurora B kinase activity, yielding elevated phosphorylation of Aurora B substrates. In contrast, here we show that elevated expression of Aurora B reduces phosphorylation of six different Aurora B substrates a...

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Detalles Bibliográficos
Autores principales: Britigan, Eric M. C., Wan, Jun, Sam, Daniel K., Copeland, Sarah E., Lasek, Amber L., Hrycyniak, Laura C. F., Wang, Lei, Audhya, Anjon, Burkard, Mark E., Roopra, Avtar, Weaver, Beth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606593/
https://www.ncbi.nlm.nih.gov/pubmed/36313574
http://dx.doi.org/10.3389/fcell.2022.1018161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606593/
https://www.ncbi.nlm.nih.gov/pubmed/36313574
http://dx.doi.org/10.3389/fcell.2022.1018161

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