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NOTCH1 Signalling: A key pathway for the development of high-risk chronic lymphocytic leukaemia
NOTCH1 is a cell surface receptor that releases its intracellular domain as transcription factor upon activation. With the advent of next-generation sequencing, the NOTCH1 gene was found recurrently mutated in chronic lymphocytic leukaemia (CLL). Here, virtually all NOTCH1 mutations affect the prote...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606825/ https://www.ncbi.nlm.nih.gov/pubmed/36313682 http://dx.doi.org/10.3389/fonc.2022.1019730 |