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The SARS-CoV-2 S1 Spike Protein Promotes MAPK and NF-kB Activation in Human Lung Cells and Inflammatory Cytokine Production in Human Lung and Intestinal Epithelial Cells

The coronavirus disease 2019 (COVID-19) pandemic began in January 2020 in Wuhan, China, with a new coronavirus designated SARS-CoV-2. The principal cause of death from COVID-19 disease quickly emerged as acute respiratory distress syndrome (ARDS). A key ARDS pathogenic mechanism is the “Cytokine Sto...

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Detalles Bibliográficos
Autores principales: Forsyth, Christopher B., Zhang, Lijuan, Bhushan, Abhinav, Swanson, Barbara, Zhang, Li, Mamede, João I., Voigt, Robin M., Shaikh, Maliha, Engen, Phillip A., Keshavarzian, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607240/
https://www.ncbi.nlm.nih.gov/pubmed/36296272
http://dx.doi.org/10.3390/microorganisms10101996