Cargando…
Coupling the Cardiac Voltage-Gated Sodium Channel to Channelrhodopsin-2 Generates Novel Optical Switches for Action Potential Studies
Voltage-gated sodium (Na(+)) channels respond to short membrane depolarization with conformational changes leading to pore opening, Na(+) influx, and action potential (AP) upstroke. In the present study, we coupled channelrhodopsin-2 (ChR2), the key ion channel in optogenetics, directly to the cardi...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607247/ https://www.ncbi.nlm.nih.gov/pubmed/36295666 http://dx.doi.org/10.3390/membranes12100907 |