Coupling the Cardiac Voltage-Gated Sodium Channel to Channelrhodopsin-2 Generates Novel Optical Switches for Action Potential Studies

Voltage-gated sodium (Na(+)) channels respond to short membrane depolarization with conformational changes leading to pore opening, Na(+) influx, and action potential (AP) upstroke. In the present study, we coupled channelrhodopsin-2 (ChR2), the key ion channel in optogenetics, directly to the cardi...

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Detalles Bibliográficos
Autores principales: vom Dahl, Christian, Müller, Christoph Emanuel, Berisha, Xhevat, Nagel, Georg, Zimmer, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607247/
https://www.ncbi.nlm.nih.gov/pubmed/36295666
http://dx.doi.org/10.3390/membranes12100907

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