The Hydrolysis Rate of Paraoxonase-1 Q and R Isoenzymes: An In Silico Study Based on In Vitro Data

Human serum paraoxonase-1 (PON1) is an important hydrolase-type enzyme found in numerous tissues. Notably, it can exist in two isozyme-forms, Q and R, that exhibit different activities. This study presents an in silico (QSAR, Docking, MD and QM/MM) study of a set of compounds on the activity towards...

Descripción completa

Detalles Bibliográficos
Autores principales: Karabulut, Sedat, Mansour, Basel, Casanola-Martin, Gerardo M., Rasulev, Bakhtiyor, Gauld, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607273/
https://www.ncbi.nlm.nih.gov/pubmed/36296373
http://dx.doi.org/10.3390/molecules27206780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607273/
https://www.ncbi.nlm.nih.gov/pubmed/36296373
http://dx.doi.org/10.3390/molecules27206780

Ejemplares similares