Novel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage

A series of 78 synthetic 7-chloro-(4-thioalkylquinoline) derivatives were investigated for cytotoxic activity against eight human cancer as well as 4 non-tumor cell lines. The results showed, with some exceptions, that sulfanyl 5–40 and sulfinyl 41–62 derivatives exhibited lower cytotoxicity for can...

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Detalles Bibliográficos
Autores principales: Gutiérrez, Joyce E., Fernandez-Moreira, Esteban, Rodríguez, Miguel A., Mijares, Michael R., De Sanctis, Juan Bautista, Gurská, Soňa, Džubák, Petr, Hajdůch, Marián, Bruno-Colmenarez, Julia, Rojas, Luis, Deffieux, Denis, Pouységu, Laurent, Quideau, Stéphane, Charris, Jaime, Ramírez, Hegira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607427/
https://www.ncbi.nlm.nih.gov/pubmed/36297346
http://dx.doi.org/10.3390/ph15101234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607427/
https://www.ncbi.nlm.nih.gov/pubmed/36297346
http://dx.doi.org/10.3390/ph15101234

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