Dual Targeting Ligands—Histamine H(3) Receptor Ligands with Monoamine Oxidase B Inhibitory Activity—In Vitro and In Vivo Evaluation

The clinical symptoms of Parkinson’s disease (PD) appear when dopamine (DA) concentrations in the striatum drops to around 20%. Simultaneous inhibitory effects on histamine H(3) receptor (H(3)R) and MAO B can increase DA levels in the brain. A series of compounds was designed and tested in vitro for...

Descripción completa

Detalles Bibliográficos
Autores principales: Łażewska, Dorota, Siwek, Agata, Olejarz-Maciej, Agnieszka, Doroz-Płonka, Agata, Wiktorowska-Owczarek, Anna, Jóźwiak-Bębenista, Marta, Reiner-Link, David, Frank, Annika, Sromek-Trzaskowska, Wioletta, Honkisz-Orzechowska, Ewelina, Królicka, Ewelina, Stark, Holger, Wieczorek, Marek, Wagner, Waldemar, Kieć-Kononowicz, Katarzyna, Stasiak, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607599/
https://www.ncbi.nlm.nih.gov/pubmed/36297622
http://dx.doi.org/10.3390/pharmaceutics14102187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607599/
https://www.ncbi.nlm.nih.gov/pubmed/36297622
http://dx.doi.org/10.3390/pharmaceutics14102187

Ejemplares similares