Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21

Physiologically based pharmacokinetic (PBPK) modeling has a number of applications, including assessing drug–drug interactions (DDIs) in polymorphic populations, and should be iteratively refined as science progresses. The Simcyp Simulator is annually updated and version 21 included updates to hepat...

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Detalles Bibliográficos
Autores principales: Sychterz, Caroline, Gardner, Iain, Chiang, Manting, Rachumallu, Ramakrishna, Neuhoff, Sibylle, Perera, Vidya, Merali, Samira, Schmidt, Brian J., Gaohua, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607610/
https://www.ncbi.nlm.nih.gov/pubmed/36295903
http://dx.doi.org/10.3390/metabo12101001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607610/
https://www.ncbi.nlm.nih.gov/pubmed/36295903
http://dx.doi.org/10.3390/metabo12101001

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