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Nicotinamide N-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE(2) Pathway

[Image: see text] Nicotinamide N-methyltransferase (NNMT) is a cytosolic methyltransferase, catalyzing N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-l-methionine (SAM) is the methyl donor. It has been well documented that NNMT is elevated in multiple...

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Detalles Bibliográficos
Autores principales: Yang, Changmei, Wang, Tianxiang, Zhu, Songbiao, Zong, Zhaoyun, Luo, Chengting, Zhao, Yujiao, Liu, Jing, Li, Ting, Liu, Xiaohui, Liu, Chongdong, Deng, Haiteng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607676/
https://www.ncbi.nlm.nih.gov/pubmed/36312432
http://dx.doi.org/10.1021/acsomega.2c04286