Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation

BOK is a poorly understood member of the BCL-2 family of proteins that has been proposed to function as a pro-apoptotic, BAX-like effector. However, the molecular mechanism and structural properties of BOK pores remain enigmatic. Here, we show that the thermal stability and pore activity of BOK depe...

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Detalles Bibliográficos
Autores principales: Shalaby, Raed, Diwan, Arzoo, Flores-Romero, Hector, Hertlein, Vanessa, Garcia-Saez, Ana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607731/
https://www.ncbi.nlm.nih.gov/pubmed/36289446
http://dx.doi.org/10.1038/s41418-022-01078-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607731/
https://www.ncbi.nlm.nih.gov/pubmed/36289446
http://dx.doi.org/10.1038/s41418-022-01078-w

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