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Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation

BOK is a poorly understood member of the BCL-2 family of proteins that has been proposed to function as a pro-apoptotic, BAX-like effector. However, the molecular mechanism and structural properties of BOK pores remain enigmatic. Here, we show that the thermal stability and pore activity of BOK depe...

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Detalles Bibliográficos
Autores principales:	Shalaby, Raed, Diwan, Arzoo, Flores-Romero, Hector, Hertlein, Vanessa, Garcia-Saez, Ana J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607731/ https://www.ncbi.nlm.nih.gov/pubmed/36289446 http://dx.doi.org/10.1038/s41418-022-01078-w

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