D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II

Glutamate carboxypeptidase-II (GCPII) is a zinc-dependent metalloenzyme implicated in numerous neurological disorders. The pharmacophoric requirements of active-site GCPII inhibitors makes them highly charged, manifesting poor pharmacokinetic (PK) properties. Herein, we describe the discovery and ch...

Descripción completa

Detalles Bibliográficos
Autores principales: Gori, Sadakatali S., Thomas, Ajit G., Pal, Arindom, Wiseman, Robyn, Ferraris, Dana V., Gao, Run-duo, Wu, Ying, Alt, Jesse, Tsukamoto, Takashi, Slusher, Barbara S., Rais, Rana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608075/
https://www.ncbi.nlm.nih.gov/pubmed/36297453
http://dx.doi.org/10.3390/pharmaceutics14102018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608075/
https://www.ncbi.nlm.nih.gov/pubmed/36297453
http://dx.doi.org/10.3390/pharmaceutics14102018

Ejemplares similares