Evaluating Allosteric Perturbations in Cannabinoid Receptor 1 by In Silico Single-Point Mutation

[Image: see text] Cannabinoid receptor 1 (CB1) is a promising drug target involved in many physiological processes. Using atomistic molecular dynamics (MD) simulations, we examined the structural effect of F237L mutation on CB1, a mutation that has qualitatively similar effects to allosteric ligand...

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Detalles Bibliográficos
Autores principales: Díaz, Oscar, Renault, Pedro, Giraldo, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608382/
https://www.ncbi.nlm.nih.gov/pubmed/36312415
http://dx.doi.org/10.1021/acsomega.2c04980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608382/
https://www.ncbi.nlm.nih.gov/pubmed/36312415
http://dx.doi.org/10.1021/acsomega.2c04980

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