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Evaluating Allosteric Perturbations in Cannabinoid Receptor 1 by In Silico Single-Point Mutation
[Image: see text] Cannabinoid receptor 1 (CB1) is a promising drug target involved in many physiological processes. Using atomistic molecular dynamics (MD) simulations, we examined the structural effect of F237L mutation on CB1, a mutation that has qualitatively similar effects to allosteric ligand...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608382/ https://www.ncbi.nlm.nih.gov/pubmed/36312415 http://dx.doi.org/10.1021/acsomega.2c04980 |