A More Sustainable Isocyanide Synthesis from N-Substituted Formamides Using Phosphorus Oxychloride in the Presence of Triethylamine as Solvent

A simple, green, and highly efficient protocol for the synthesis of isocyanides is described. The reaction involves dehydration of formamides with phosphorus oxychloride in the presence of triethylamine as solvent at 0 °C. The product isocyanides were obtained in high to excellent yields in less tha...

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Detalles Bibliográficos
Autores principales: Salami, Sodeeq Aderotimi, Siwe-Noundou, Xavier, Krause, Rui Werner Maçedo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608669/
https://www.ncbi.nlm.nih.gov/pubmed/36296444
http://dx.doi.org/10.3390/molecules27206850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608669/
https://www.ncbi.nlm.nih.gov/pubmed/36296444
http://dx.doi.org/10.3390/molecules27206850

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