Cargando…

HLA-B*27 Heavy Chain Homo-Oligomers Promote the Cytotoxicity of NK Cells via Activation of PI3K/AKT Signaling

Background and Objectives: Ankylosing spondylitis (AS) is a chronic inflammatory disease and is highly linked with the expression of the human leukocytic antigen-B*27 (HLA-B*27) genotype. HLA-B*27 heavy chain (B*27-HC) has an innate characteristic to slowly fold, resulting in the accumulation of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Hui-Chun, Huang, Kuang-Yung, Lu, Ming-Chi, Huang Tseng, Hsien-Yu, Liu, Su-Qin, Lai, Ning-Sheng, Huang, Hsien-Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608704/ https://www.ncbi.nlm.nih.gov/pubmed/36295572 http://dx.doi.org/10.3390/medicina58101411

Ejemplares similares

Sulfasalazine Treatment Suppresses the Formation of HLA-B27 Heavy Chain Homodimer in Patients with Ankylosing Spondylitis
por: Yu, Hui-Chun, et al.
Publicado: (2015)

Characterization of the Recognition Specificity of BH2, a Monoclonal Antibody Prepared against the HLA-B27 Heavy Chain
por: Yu, Hui-Chun, et al.
Publicado: (2015)

AKAP5 and AKAP12 Form Homo-oligomers
por: Gao, Shujuan, et al.
Publicado: (2011)

Targeted Delivery of the HLA-B(∗)27-Binding Peptide into the Endoplasmic Reticulum Suppresses the IL-23/IL-17 Axis of Immune Cells in Spondylarthritis
por: Yu, Hui-Chun, et al.
Publicado: (2017)

PELDOR in rotationally symmetric homo-oligomers
por: Giannoulis, Angeliki, et al.
Publicado: (2013)

The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain
Publicado: (1994)

Computational Design of Self-Assembling Cyclic Protein Homo-oligomers
por: Fallas, Jorge A., et al.
Publicado: (2016)

Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations
por: Gao, Linfeng, et al.
Publicado: (2022)

HSYMDOCK: a docking web server for predicting the structure of protein homo-oligomers with Cn or Dn symmetry
por: Yan, Yumeng, et al.
Publicado: (2018)

Stoichiometry of HLA Class II-Invariant Chain Oligomers
por: Koch, Norbert, et al.
Publicado: (2011)

Down-Regulation of LOC645166 in T Cells of Ankylosing Spondylitis Patients Promotes the NF-κB Signaling via Decreasingly Blocking Recruitment of the IKK Complex to K63-Linked Polyubiquitin Chains
por: Yu, Hui-Chun, et al.
Publicado: (2021)

Induction of HLA-B27 heavy chain homodimer formation after activation in dendritic cells
por: Santos, Susana G, et al.
Publicado: (2008)

The types II and III transforming growth factor-beta receptors form homo-oligomers
Publicado: (1994)

Modeling protein quaternary structure of homo- and hetero-oligomers beyond binary interactions by homology
por: Bertoni, Martino, et al.
Publicado: (2017)

Organic anion transporting polypeptide 1B3 can form homo- and hetero-oligomers
por: Zhang, Yuchen, et al.
Publicado: (2017)

The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09
por: Cauli, Alberto, et al.
Publicado: (2013)

Two Arabidopsis Chloroplast GrpE Homologues Exhibit Distinct Biological Activities and Can Form Homo- and Hetero-Oligomers
por: Su, Pai-Hsiang, et al.
Publicado: (2020)

Site specific NMR characterization of abeta-40 oligomers cross seeded by abeta-42 oligomers
por: Chang, Han-Wen, et al.
Publicado: (2022)

Association of ORAI1 Haplotypes with the Risk of HLA-B27 Positive Ankylosing Spondylitis
por: Wei, James Cheng-Chung, et al.
Publicado: (2011)

AKAP12 and AKAP5 form higher-order hetero-oligomers
por: Gao, Shujuan, et al.
Publicado: (2011)

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity
por: Li, Dapeng, et al.
Publicado: (2022)

Degradation of neurodegenerative disease-associated TDP-43 aggregates and oligomers via a proteolysis-targeting chimera
por: Tseng, Yu-Ling, et al.
Publicado: (2023)

Nanoscopic Insights of Amphiphilic Peptide against the Oligomer Assembly Process to Treat Huntington's Disease
por: He, Ruei‐Yu, et al.
Publicado: (2019)

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage
por: Shafiei, Scott S., et al.
Publicado: (2017)

XPO1 inhibition sensitises CLL cells to NK cell mediated cytotoxicity and overcomes HLA-E expression
por: Fisher, Jack G., et al.
Publicado: (2023)

Rapamycin Synergizes with Cisplatin in Antiendometrial Cancer Activation by Improving IL-27–Stimulated Cytotoxicity of NK Cells
por: Zhou, Wen-Jie, et al.
Publicado: (2017)

GalaxyHomomer: a web server for protein homo-oligomer structure prediction from a monomer sequence or structure
por: Baek, Minkyung, et al.
Publicado: (2017)

MRI contributes to accurate and early diagnosis of non-radiographic HLA-B27 negative axial spondyloarthritis
por: Lu, Chun-Chi, et al.
Publicado: (2021)

IL-27 Driven Upregulation of Surface HLA-E Expression on Monocytes Inhibits IFN-γ Release by Autologous NK Cells
por: Morandi, Fabio, et al.
Publicado: (2014)

p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction
por: Wong, Derek P., et al.
Publicado: (2023)

RSC96 Schwann Cell Proliferation and Survival Induced by Dilong through PI3K/Akt Signaling Mediated by IGF-I
por: Chang, Yung-Ming, et al.
Publicado: (2011)

Unique Properties of the Rabbit Prion Protein Oligomer
por: Yu, Ziyao, et al.
Publicado: (2016)

Activation of Cytotoxic and Regulatory Functions of NK Cells by Sindbis Viral Vectors
por: Granot, Tomer, et al.
Publicado: (2011)

The Flavodiiron Protein Flv3 Functions as a Homo-Oligomer During Stress Acclimation and is Distinct from the Flv1/Flv3 Hetero-Oligomer Specific to the O(2) Photoreduction Pathway
por: Mustila, Henna, et al.
Publicado: (2016)

MET and AKT Genetic Influence on Facial Emotion Perception
por: Lin, Ming-Teng, et al.
Publicado: (2012)

Regulation of NK-Cell Function by HLA Class II
por: Niehrs, Annika, et al.
Publicado: (2020)

KIR/HLA genotype combinations are determinants of Natural Killer (NK) cell mediated antibody-dependent cellular cytotoxicity (ADCC) potency
por: Parsons, MS, et al.
Publicado: (2012)

Role of HLA-G and NCR in protection of umbilical cord blood haematopoietic stem cells from NK cell mediated cytotoxicity
por: Wang, Ming, et al.
Publicado: (2011)

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events
por: Bhaskar, Kiran, et al.
Publicado: (2009)

Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells
por: Lin, Jiajia, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3ss3kbc73583g0llfisiq61ggs