GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma

BACKGROUND: Glaucoma, the major cause of irreversible blindness worldwide, is characterized by progressive degeneration of retinal ganglion cells (RGCs). Current treatments for glaucoma only slow or partially prevent the disease progression, failing to prevent RGCs death and visual field defects com...

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Detalles Bibliográficos
Autores principales: Liu, Mengyuan, Li, Haibo, Yang, Rongliang, Ji, Dan, Xia, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608931/
https://www.ncbi.nlm.nih.gov/pubmed/36289519
http://dx.doi.org/10.1186/s12974-022-02626-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608931/
https://www.ncbi.nlm.nih.gov/pubmed/36289519
http://dx.doi.org/10.1186/s12974-022-02626-4

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