A stratified adaptive two-stage design with co-primary endpoints for phase II clinical oncology trials

BACKGROUND: Given the inherent challenges of conducting randomized phase III trials in older cancer patients, single-arm phase II trials which assess the feasibility of a treatment that has already been shown to be effective in a younger population may provide a compelling alternative. Such an appro...

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Detalles Bibliográficos
Autores principales: Cabarrou, Bastien, Leconte, Eve, Sfumato, Patrick, Boher, Jean-Marie, Filleron, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608934/
https://www.ncbi.nlm.nih.gov/pubmed/36289451
http://dx.doi.org/10.1186/s12874-022-01748-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608934/
https://www.ncbi.nlm.nih.gov/pubmed/36289451
http://dx.doi.org/10.1186/s12874-022-01748-w

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