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A stratified adaptive two-stage design with co-primary endpoints for phase II clinical oncology trials
BACKGROUND: Given the inherent challenges of conducting randomized phase III trials in older cancer patients, single-arm phase II trials which assess the feasibility of a treatment that has already been shown to be effective in a younger population may provide a compelling alternative. Such an appro...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608934/ https://www.ncbi.nlm.nih.gov/pubmed/36289451 http://dx.doi.org/10.1186/s12874-022-01748-w |