Computational Design, Synthesis, and Pharmacological Evaluation of Naproxen-Guaiacol Chimera for Gastro-Sparing Anti-Inflammatory Response by Selective COX2 Inhibition

The 4-allyl guaiacol is a natural phenolic molecule that has been widely studied for its antioxidant capacity against reactive-oxygen-species-mediated cellular damage. Therefore, we hypothesized that concomitant use of an antioxidant and NSAID may decrease the risk of gastrointestinal toxicity and m...

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Detalles Bibliográficos
Autores principales: Shinu, Pottathil, Sharma, Manu, Gupta, Girdhari Lal, Mujwar, Somdutt, Kandeel, Mahmoud, Kumar, Manish, Nair, Anroop B., Goyal, Manoj, Singh, Purna, Attimarad, Mahesh, Venugopala, Katharigatta N., Nagaraja, Sreeharsha, Telsang, Mallikarjun, Aldhubiab, Bandar E., Morsy, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609004/
https://www.ncbi.nlm.nih.gov/pubmed/36296501
http://dx.doi.org/10.3390/molecules27206905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609004/
https://www.ncbi.nlm.nih.gov/pubmed/36296501
http://dx.doi.org/10.3390/molecules27206905

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