Cargando…

Computational Design, Synthesis, and Pharmacological Evaluation of Naproxen-Guaiacol Chimera for Gastro-Sparing Anti-Inflammatory Response by Selective COX2 Inhibition

The 4-allyl guaiacol is a natural phenolic molecule that has been widely studied for its antioxidant capacity against reactive-oxygen-species-mediated cellular damage. Therefore, we hypothesized that concomitant use of an antioxidant and NSAID may decrease the risk of gastrointestinal toxicity and m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shinu, Pottathil, Sharma, Manu, Gupta, Girdhari Lal, Mujwar, Somdutt, Kandeel, Mahmoud, Kumar, Manish, Nair, Anroop B., Goyal, Manoj, Singh, Purna, Attimarad, Mahesh, Venugopala, Katharigatta N., Nagaraja, Sreeharsha, Telsang, Mallikarjun, Aldhubiab, Bandar E., Morsy, Mohamed A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609004/ https://www.ncbi.nlm.nih.gov/pubmed/36296501 http://dx.doi.org/10.3390/molecules27206905

Ejemplares similares

Formulation and Evaluation of Self-Nanoemulsifying Drug Delivery System Derived Tablet Containing Sertraline
por: Nair, Anroop B., et al.
Publicado: (2022)

Development and Validation of Green UV Derivative Spectrophotometric Methods for Simultaneous Determination Metformin and Remogliflozin from Formulation: Evaluation of Greenness
por: Attimarad, Mahesh, et al.
Publicado: (2021)

Intranasal Delivery of Darunavir-Loaded Mucoadhesive In Situ Gel: Experimental Design, In Vitro Evaluation, and Pharmacokinetic Studies
por: Nair, Anroop B., et al.
Publicado: (2022)

Experimental design, formulation and in vivo evaluation of a novel topical in situ gel system to treat ocular infections
por: Nair, Anroop B., et al.
Publicado: (2021)

HPMC- and PLGA-Based Nanoparticles for the Mucoadhesive Delivery of Sitagliptin: Optimization and In Vivo Evaluation in Rats
por: Nair, Anroop B., et al.
Publicado: (2019)

Design, Development, and Evaluation of Constant Voltage Iontophoresis for the Transungual Delivery of Efinaconazole
por: Nair, Anroop B., et al.
Publicado: (2023)

Clarithromycin Solid Lipid Nanoparticles for Topical Ocular Therapy: Optimization, Evaluation, and In Vivo Studies
por: Nair, Anroop B., et al.
Publicado: (2021)

Computational, crystallographic studies, cytotoxicity and anti-tubercular activity of substituted 7-methoxy-indolizine analogues
por: Venugopala, Katharigatta Narayanaswamy, et al.
Publicado: (2019)

Effective Therapeutic Delivery and Bioavailability Enhancement of Pioglitazone Using Drug in Adhesive Transdermal Patch
por: Nair, Anroop B., et al.
Publicado: (2019)

Development of Asialoglycoprotein Receptor-Targeted Nanoparticles for Selective Delivery of Gemcitabine to Hepatocellular Carcinoma
por: Nair, Anroop B., et al.
Publicado: (2019)

Monitoring of Non-β-Lactam Antibiotic Resistance-Associated Genes in ESBL Producing Enterobacterales Isolates
por: Shinu, Pottathil, et al.
Publicado: (2020)

Correction: Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
por: Attimarad, Mahesh, et al.
Publicado: (2019)

Progress Report: Antimicrobial Drug Discovery in the Resistance Era
por: Shinu, Pottathil, et al.
Publicado: (2022)

An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles
por: SreeHarsha, Nagaraja, et al.
Publicado: (2019)

Constant Voltage Iontophoresis Technique to Deliver Terbinafine via Transungual Delivery System: Formulation Optimization Using Box–Behnken Design and In Vitro Evaluation
por: Nair, Anroop B., et al.
Publicado: (2021)

Crystallography, Molecular Modeling, and COX-2 Inhibition Studies on Indolizine Derivatives
por: Venugopala, Katharigatta N., et al.
Publicado: (2021)

Formulation, Characterization, Anti-Inflammatory and Cytotoxicity Study of Sesamol-Laden Nanosponges
por: Nair, Anroop B., et al.
Publicado: (2022)

Solid Lipid Nanoparticles Embedded Hydrogels as a Promising Carrier for Retarding Irritation of Leflunomide
por: Alhelal, Hawra Mohammed, et al.
Publicado: (2023)

Anti-Tubercular Activity of Substituted 7-Methyl and 7-Formylindolizines and In Silico Study for Prospective Molecular Target Identification
por: Venugopala, Katharigatta N., et al.
Publicado: (2019)

Sensitivity Enhanced Ecofriendly UV Spectrophotometric Methods for Quality Control of Telmisartan and Benidipine Formulations: Comparison of Whiteness and Greenness with HPLC Methods
por: Chohan, Muhammad Shahzad, et al.
Publicado: (2022)

1,2,3-Triazolyl-tetrahydropyrimidine Conjugates as Potential Sterol Carrier Protein-2 Inhibitors: Larvicidal Activity against the Malaria Vector Anopheles arabiensis and In Silico Molecular Docking Study
por: Venugopala, Katharigatta N., et al.
Publicado: (2022)

Antitubercular, Cytotoxicity, and Computational Target Validation of Dihydroquinazolinone Derivatives
por: Venugopala, Katharigatta N., et al.
Publicado: (2022)

In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis
por: Venugopala, Katharigatta N, et al.
Publicado: (2020)

Novel Series of Methyl 3-(Substituted Benzoyl)-7-Substituted-2-Phenylindolizine-1-Carboxylates as Promising Anti-Inflammatory Agents: Molecular Modeling Studies
por: Venugopala, Katharigatta N., et al.
Publicado: (2019)

Development of Novel Unfolding Film System of Itopride Hydrochloride Using Box-Behnken Design—A Gastro Retentive Approach
por: Alaithan, Shaima, et al.
Publicado: (2022)

Papain-cetylpyridinium chloride and pepsin-cetylpyridinium chloride; two novel, highly sensitive, concentration, digestion and decontamination techniques for culturing mycobacteria from clinically suspected pulmonary tuberculosis cases
por: Shinu, Pottathil, et al.
Publicado: (2020)

Camel Proteins and Enzymes: A Growing Resource for Functional Evolution and Environmental Adaptation
por: Kandeel, Mahmoud, et al.
Publicado: (2022)

Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential
por: Shinu, Pottathil, et al.
Publicado: (2023)

Cytotoxicity and Antimycobacterial Properties of Pyrrolo[1,2-a]quinoline Derivatives: Molecular Target Identification and Molecular Docking Studies
por: Venugopala, Katharigatta N., et al.
Publicado: (2020)

Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation
por: Nair, Anroop B., et al.
Publicado: (2021)

Larvicidal Activities of 2-Aryl-2,3-Dihydroquinazolin -4-ones against Malaria Vector Anopheles arabiensis, In Silico ADMET Prediction and Molecular Target Investigation
por: Venugopala, Katharigatta N., et al.
Publicado: (2020)

Mucoadhesive Particles: A Novel, Prolonged-Release Nanocarrier of Sitagliptin for the Treatment of Diabetics
por: SreeHarsha, Nagaraja, et al.
Publicado: (2019)

Crystallography, in Silico Studies, and In Vitro Antifungal Studies of 2,4,5 Trisubstituted 1,2,3-Triazole Analogues
por: Venugopala, Katharigatta N., et al.
Publicado: (2020)

Tocotrienol in the Treatment of Topical Wounds: Recent Updates
por: Nair, Anroop B., et al.
Publicado: (2022)

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management
por: Jacob, Shery, et al.
Publicado: (2021)

Lipid Nanoparticles as a Promising Drug Delivery Carrier for Topical Ocular Therapy—An Overview on Recent Advances
por: Jacob, Shery, et al.
Publicado: (2022)

Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls
por: Shinu, Pottathil, et al.
Publicado: (2022)

Carnosine Potentiates Doxorubicin-Induced Cytotoxicity in Resistant NCI/ADR-RES Cells by Inhibiting P-Glycoprotein—In Silico and In Vitro Evidence
por: Morsy, Mohamed A., et al.
Publicado: (2022)

Qbd-Based Approach to Optimize Niosomal Gel of Levosulpiride for Transdermal Drug Delivery
por: Alnaim, Ahmed S., et al.
Publicado: (2023)

Paeonol Attenuates Hepatic Ischemia/Reperfusion Injury by Modulating the Nrf2/HO-1 and TLR4/MYD88/NF-κB Signaling Pathways
por: Morsy, Mohamed A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3e5r1e72804vehdedkmtrv5l5m