Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice

Alzheimer’s disease (AD) is characterized by the progressive accumulation of amyloid-β and hyperphosphorylated tau (pTau), which can spread throughout the brain via extracellular vesicles (EVs). Membrane ceramide enrichment regulated by the enzyme neutral sphingomyelinase 2 (nSMase2) is a critical c...

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Detalles Bibliográficos
Autores principales: Tallon, Carolyn, Bell, Benjamin J., Sharma, Anjali, Pal, Arindom, Malvankar, Medhinee M., Thomas, Ajit G., Yoo, Seung-Wan, Hollinger, Kristen R., Coleman, Kaleem, Wilkinson, Elizabeth L., Kannan, Sujatha, Haughey, Norman J., Kannan, Rangaramanujam M., Rais, Rana, Slusher, Barbara S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609094/
https://www.ncbi.nlm.nih.gov/pubmed/36297501
http://dx.doi.org/10.3390/pharmaceutics14102066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609094/
https://www.ncbi.nlm.nih.gov/pubmed/36297501
http://dx.doi.org/10.3390/pharmaceutics14102066

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