Targeting the Bet-Hedging Strategy with an Inhibitor of Bacterial Efflux Capacity Enhances Antibiotic Efficiency and Ameliorates Bacterial Persistence In Vitro

Persistence is a bet-hedging strategy in bacterial populations that increases antibiotic tolerance and leads to the establishment of latent infections. In this study, we demonstrated that a synthetic non-toxic taxane-based reversal agent (tRA), developed as an inhibitor of ABC transporter systems in...

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Detalles Bibliográficos
Autores principales: Morales, Demosthenes, Micheva-Viteva, Sofiya, Adikari, Samantha, Werner, James, Wolinsky, Murray, Hong-Geller, Elizabeth, Kim, Jinwoo, Ojima, Iwao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609472/
https://www.ncbi.nlm.nih.gov/pubmed/36296242
http://dx.doi.org/10.3390/microorganisms10101966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609472/
https://www.ncbi.nlm.nih.gov/pubmed/36296242
http://dx.doi.org/10.3390/microorganisms10101966

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