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In Silico Studies on GCP-Lys-OMe as a Potential 14-3-3σ Homodimer Stabilizer
14-3-3 sigma is a vital negative cell cycle regulator. Its expression is consistently downregulated in many types of cancer through gene promoter hypermethylation or proteasomal degradation. 14-3-3 sigma needs to form a homodimer to be functional, while dimers are less prone to degradation than mono...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609495/ https://www.ncbi.nlm.nih.gov/pubmed/36297403 http://dx.doi.org/10.3390/ph15101290 |