Cargando…

Identification of Natural Compounds as Inhibitors of Pyruvate Kinase M2 for Cancer Treatment

The reliance of tumor cells on aerobic glycolysis is one of the emerging hallmarks of cancer. Pyruvate kinase M2 (PKM2), an important enzyme of glycolytic pathway, is highly expressed in a number of cancer cells. Tumor cells heavily depend on PKM2 to fulfill their divergent energetic and biosyntheti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sarfraz, Iqra, Rasul, Azhar, Jabeen, Farhat, Sultana, Tayyaba, Adem, Şevki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609560/ https://www.ncbi.nlm.nih.gov/pubmed/36296707 http://dx.doi.org/10.3390/molecules27207113

Ejemplares similares

Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (M(pro)) inhibitors to unveil a hope against COVID-19
por: Adem, Şevki, et al.
Publicado: (2022)

Identification of Macrolepiota procera extract as a novel G6PD inhibitor for the treatment of lung cancer
por: Zara, Rabia, et al.
Publicado: (2022)

Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment
por: Sadiqa, Ayesha, et al.
Publicado: (2022)

Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways
por: Sarfraz, Ayesha, et al.
Publicado: (2020)

Mangifera indica Extracts as Novel PKM2 Inhibitors for Treatment of Triple Negative Breast Cancer
por: Rasul, Azhar, et al.
Publicado: (2021)

Caffeic acid derivatives (CAFDs) as inhibitors of SARS-CoV-2: CAFDs-based functional foods as a potential alternative approach to combat COVID-19
por: Adem, Şevki, et al.
Publicado: (2021)

Fraxinus: A Plant with Versatile Pharmacological and Biological Activities
por: Sarfraz, Iqra, et al.
Publicado: (2017)

Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
por: Zhou, Xiaoli, et al.
Publicado: (2016)

Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities
por: Riaz, Ammara, et al.
Publicado: (2018)

Dissecting the Role of SMYD2 and Its Inhibitor (LLY-507) in the Treatment of Chemically Induced Non-Small Cell Lung Cancer (NSCLC) by Using Fe(3)O(4) Nanoparticles Drug Delivery System
por: Munawwar, Aasma, et al.
Publicado: (2023)

Hepatoprotective effects of almond shells against carbon tetrachloride induced liver injury in albino rats
por: Zahira, Andleeb, et al.
Publicado: (2023)

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis
por: Zhan, Cheng, et al.
Publicado: (2015)

Identification of Lignan Compounds as New 6-Phosphogluconate Dehydrogenase Inhibitors for Lung Cancer
por: Khan, Gul Bushra, et al.
Publicado: (2022)

Protein kinase function of pyruvate kinase M2 and cancer
por: Chen, Xun, et al.
Publicado: (2020)

The role of pyruvate kinase M2 in anticancer therapeutic treatments
por: Su, Qiongli, et al.
Publicado: (2019)

Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia
por: Li, Jing, et al.
Publicado: (2018)

Parkin Regulates the Activity of Pyruvate Kinase M2
por: Liu, Kun, et al.
Publicado: (2016)

Pyruvate Kinase M2 Expression, but Not Pyruvate Kinase Activity, Is Up-Regulated in a Grade-Specific Manner in Human Glioma
por: Mukherjee, Joydeep, et al.
Publicado: (2013)

Effect of PENN-DIABEX, a novel polyherbal formulation, in high fat diet streptozotocin-induced diabetic rats
por: Hassan, Mudassir, et al.
Publicado: (2023)

Synthesis and characterization of Guar gum based biopolymeric hydrogels as carrier materials for controlled delivery of methotrexate to treat colon cancer
por: Zarbab, Aneeqa, et al.
Publicado: (2023)

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis
por: Zhou, Haiping, et al.
Publicado: (2016)

Molecular docking analysis of pyruvate kinase M2 with a potential inhibitor from the ZINC database
por: Sharma, Pankaj, et al.
Publicado: (2021)

Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase
por: Battisti, Umberto Maria, et al.
Publicado: (2022)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

A Novel Pyruvate Kinase M2 Activator Compound that Suppresses Lung Cancer Cell Viability under Hypoxia
por: Kim, Dong Joon, et al.
Publicado: (2015)

Specific Pyruvate Kinase M2 Inhibitor, Compound 3K, Induces Autophagic Cell Death through Disruption of the Glycolysis Pathway in Ovarian Cancer Cells
por: Park, Jae Hyeon, et al.
Publicado: (2021)

Compounds from Natural Sources as Protein Kinase Inhibitors
por: Baier, Andrea, et al.
Publicado: (2020)

Cryptosporidium parvum Pyruvate Kinase Inhibitors With in vivo Anti-cryptosporidial Efficacy
por: Khan, Shahbaz M., et al.
Publicado: (2022)

Novel Specific Pyruvate Kinase M2 Inhibitor, Compound 3h, Induces Apoptosis and Autophagy through Suppressing Akt/mTOR Signaling Pathway in LNCaP Cells
por: Jiang, Chunxue, et al.
Publicado: (2022)

Pyruvate Kinase M2: A Potential Target for Regulating Inflammation
por: Alves-Filho, Jose C., et al.
Publicado: (2016)

Pyruvate kinase M2 regulates photoreceptor structure, function, and viability
por: Rajala, Ammaji, et al.
Publicado: (2018)

Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer
por: Prakasam, Gopinath, et al.
Publicado: (2018)

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor
por: Yuan, Meng, et al.
Publicado: (2018)

Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation
por: Mitchell, Alice Rose, et al.
Publicado: (2018)

The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells
por: Kurihara-Shimomura, Miyako, et al.
Publicado: (2018)

Protein Stability of Pyruvate Kinase Isozyme M2 Is Mediated by HAUSP
por: Choi, Hae-Seul, et al.
Publicado: (2020)

Pyruvate kinase M1 regulates butyrate metabolism in cancerous colonocytes
por: Park, Bohye, et al.
Publicado: (2022)

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
por: Davidson, Shawn M., et al.
Publicado: (2022)

Pinocembrin: A Novel Natural Compound with Versatile Pharmacological and Biological Activities
por: Rasul, Azhar, et al.
Publicado: (2013)

Salvianolic acid A & B: potential cytotoxic polyphenols in battle against cancer via targeting multiple signaling pathways
por: Qin, Tian, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_fb1re0sruoltvobfr1ve0ml4bb