Tumor Suppressor p53 Inhibits Hepatitis B Virus Replication by Downregulating HBx via E6AP-Mediated Proteasomal Degradation in Human Hepatocellular Carcinoma Cell Lines

HBx, a multifunctional regulatory protein, plays an essential role in the replication and pathogenesis of the hepatitis B virus (HBV). In this study, we found that in human hepatoma cells, the tumor suppressor p53 downregulates HBx via ubiquitin-dependent proteasomal degradation. p53 transcriptional...

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Detalles Bibliográficos
Autores principales: Lim, Ha-Yeon, Han, Jiwoo, Yoon, Hyunyoung, Jang, Kyung Lib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609658/
https://www.ncbi.nlm.nih.gov/pubmed/36298868
http://dx.doi.org/10.3390/v14102313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609658/
https://www.ncbi.nlm.nih.gov/pubmed/36298868
http://dx.doi.org/10.3390/v14102313

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